Anti-inflammatory agent 49

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Anti-inflammatory agent 49 (化合物 SC9) 是Drp1-Fis1 相互作用的抑制剂，可以减轻Fis1介导的线粒体功能障碍。Anti-inflammatory agent 49 体外抑制GTPase 的IC50 为270 nM。

nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM.

Cell Viability Assay Cell Line:H9c2 cells Concentration:2 μM Incubation Time:16?h Result:Decreased the percentage of cells with fragmented mitochondria. The percent of fragmented cells was decreased from 22% (LPS + Veh) to 9% (LPS + SC9), relative to 4% in the absence of LPS.Western Blot Analysis Cell Line:H9c2 cells Concentration:2 μM Incubation Time:24?h Result:Decreased the number of high Drp1-Fis1 cells from 67% (LPS + Veh) to 28% (LPS + P110) and to 14% (LPS + SC9).

Animal Model:Female BALB/c AnNCrl micee (Strain Code 028)Dosage:LPS doses 10–16.67 mg/kg, SC9 doses 10 mg/kg(after 4 h) Administration:Intraperitoneal injection: 0.2 mL of LPS,0.1 mL of CS9; scored every 8 h for 72 h.Result:Improved mouse survival at all LPS doses tested at the different LPS doses (10 to 16.6 mg/kg) .Dramatically reduced the occurrence of critical symptoms such as respiratory distress.

——

Others

Other Targets

GTPase

——

——

851471-44-8

466.52

C21H22N8O3S

>98% (HPLC)

——

O=C1NC(=O)N(C(N)=C1N(C(=O)CSC=2N=C3N=C(C=C(N3N2)C)C)C)CC=4C=CC=CC4

——

(-20℃)

With Ice Pack

≥ 2 years